Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR1B | P28222 | 3/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161931 | 0.89 | GPR17 (0.41) | PARP1HPGDCYP2C19APEX1GPR17 | |
| SCHEMBL4169903 | 0.87 | HTR1A (0.47) | PARP1HPGDCYP2C19APEX1GPR17 | |
| SCHEMBL4159922 | 0.85 | HPGD (0.41) | PARP1HPGDCYP2C19APEX1GPR17 | |
| SCHEMBL4155432 | 0.84 | CYP2C19 (0.44) | PARP1HPGDCYP2C19GPR17CYP1A2 | |
| SCHEMBL3255989 | 0.82 | PARP1 (0.47) | PARP1HPGDAPEX1HTR7CYP1A2 | |
| SCHEMBL4169910 | 0.82 | HPGD (0.44) | PARP1HPGDCYP2C19APEX1GPR17 | |
| SCHEMBL4160621 | 0.82 | MPO (0.49) | HPGDCYP2C19GPR17HTR1ATSHR | |
| SCHEMBL4165123 | 0.82 | HPGD (0.63) | PARP1HPGDCYP2C19APEX1GPR17 | |
| SCHEMBL4162937 | 0.81 | PARP1 (0.51) | PARP1HSD17B10MEN1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL4161691 | 0.81 | HPGD (0.62) | PARP1HPGDCYP2C19APEX1GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | PARP1 628/4885HPGD 882/4885CYP2C19 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.