Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | PDE8A | O60658 | 9/20 | 0.54 |
| ▸ | YTHDC1 | Q96MU7 | 7/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234771 | 0.90 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL2060472 | 0.83 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL7744345 | 0.82 | PDE8A (0.57) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL3919969 | 0.82 | YTHDC1 (0.70) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL4236128 | 0.81 | YTHDC1 (0.71) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL3957881 | 0.80 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3959301 | 0.79 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL4057371 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5466476 | 0.79 | YTHDC1 (0.55) | PDE4APDE4BPDE4CPDE4DPDE8A | |
| SCHEMBL3959347 | 0.78 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |