Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8A | O60658 | 9/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | YTHDC1 | Q96MU7 | 8/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060472 | 0.86 | PDE4A (0.67) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3919969 | 0.85 | YTHDC1 (0.70) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4236128 | 0.83 | YTHDC1 (0.71) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4172230 | 0.82 | PDE4A (0.64) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5466476 | 0.81 | YTHDC1 (0.55) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL448640 | 0.81 | ADORA2A (0.71) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL17144109 | 0.81 | ADORA2A (0.60) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13596787 | 0.80 | PDE8A (0.62) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4470318 | 0.79 | PDE8A (0.58) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2060052 | 0.78 | YTHDC1 (0.57) | PDE8APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708781-B1 | A 3 ADENOSINE RECEPTOR AGONISTS | USA (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0708781-A1 | A 3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002604-A1 | A3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-01-26 | — | — | WO | disclosed |