Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15525147 | 0.84 | ALDH1A1 (0.59) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL15525132 | 0.84 | ALDH1A1 (0.59) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL2075032 | 0.84 | ALDH1A1 (0.59) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL212100 | 0.81 | LCK (0.54) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL20451998 | 0.81 | RAB9A (0.52) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL2075811 | 0.81 | ALDH1A1 (0.52) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL20451992 | 0.81 | ALDH1A1 (0.52) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL6362765 | 0.77 | ALDH1A1 (0.49) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL4800949 | 0.77 | ALDH1A1 (0.49) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL14955176 | 0.77 | ALDH1A1 (0.61) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | ALDH1A1 2743/4885RAB9A 2128/4885SMN1; SMN2 2335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.