⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186606 | 0.83 | L3MBTL3 (0.34) | — | |
| SCHEMBL4178174 | 0.81 | OPRL1 (0.35) | — | |
| SCHEMBL14494674 | 0.78 | IDH1 (0.32) | — | |
| SCHEMBL15194037 | 0.77 | SIGMAR1 (0.35) | — | |
| SCHEMBL4172343 | 0.73 | IRAK4 (0.31) | — | |
| SCHEMBL4186626 | 0.73 | IRAK4 (0.30) | — | |
| SCHEMBL4173229 | 0.73 | EBP (0.32) | — | |
| SCHEMBL13697389 | 0.72 | — | — | |
| SCHEMBL13697390 | 0.72 | — | — | |
| SCHEMBL13697392 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | AMGEN INC. (US) | 2009-09-10 | — | — | US | disclosed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |