Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542452 | 0.82 | CHRM1 (0.46) | CHRM1CHRM2HMOX1CHRNA7 | |
| SCHEMBL1542861 | 0.82 | CHRM1 (0.46) | CHRM1CHRM2HMOX1CHRNA7 | |
| SCHEMBL1542863 | 0.82 | CHRM1 (0.46) | CHRM1CHRM2HMOX1CHRNA7 | |
| SCHEMBL1146472 | 0.79 | CHRNA7 (0.47) | CHRM1CHRM2CHRNA7 | |
| SCHEMBL1146473 | 0.79 | CHRNA7 (0.47) | CHRM1CHRM2CHRNA7 | |
| SCHEMBL1146361 | 0.76 | HTR3A (0.36) | CHRM1CHRM2CHRNA7 | |
| SCHEMBL1146358 | 0.76 | HTR3A (0.36) | CHRM1CHRM2CHRNA7 | |
| SCHEMBL1146304 | 0.74 | SCD5 (0.39) | CHRM1CHRM2 | |
| SCHEMBL1145826 | 0.73 | CHRNA7 (0.38) | CHRNA7 | |
| SCHEMBL1145822 | 0.73 | CHRNA7 (0.38) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140113908-A1 | [(1H-INDOL-5-YL) - HETEROARYLOXY] - (1-AZA-BICYCLO [3.3.1] NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENRATIVE DISORDERS | NOVARTIS AG (CH) | 2014-04-24 | — | — | US | disclosed |
| US-8637517-B2 | Organic compounds | NOVARTIS AG (CH) | 2014-01-28 | — | — | US | disclosed |
| US-20120022074-A1 | ORGANIC COMPOUNDS | NOVARTIS AG | 2012-01-26 | — | — | US | disclosed |
| US-8048885-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-01 | — | — | US | disclosed |
| EP-1966209-B1 | [ 1H- INDOL- 5 -YL) -HETEROARYLOXY] - (1-AZA-BICYCLO [3.3.1] NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS | NOVARTIS AG (CH) | 2011-10-19 | — | — | EP | disclosed |
| EP-2361914-A1 | [(1H-INDOL-5-YL)-HETEROARYLOXY]-(1-AZA-BICYCLO[3.3.1]NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENRATIVE DISORDERS. | Novartis AG (CH) | 2011-08-31 | — | — | EP | disclosed |
| US-20100179160-A1 | ORGANIC COMPOUNDS | NOVARTIS AG | 2010-07-15 | — | — | US | disclosed |
| US-7713976-B2 | [(1H-indol-5-yl)-heteroaryloxy]-1-aza-bicylco[3.3.1]nonanes as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | disclosed |
| US-20080293731-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-11-27 | — | — | US | disclosed |
| EP-1966209-A1 | [ 1H- INDOL- 5 -YL) -HETEROARYLOXY] - (1-AZA-BICYCLO [3.3.1] NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS. | Novartis AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068476-A1 | [ (1H- INDOL- 5 -YL) -HETEROARYLOXY] - (1-AZA-BICYCLO [3.3.1] NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENRATIVE DISORDERS. | NOVARTIS AG (CH) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022074-A1 | ORGANIC COMPOUNDS | TPMT, DNMT1, DNMT3L | CHRM1 1313/4885CHRM2 1798/4885HMOX1 2622/4885 |
| US-20080293731-A1 | Organic Compounds | CYP1B1, CYP2B6, UGT2B7 | CHRM1 977/4885CHRM2 1697/4885HMOX1 2721/4885 |
| US-20140113908-A1 | [(1H-INDOL-5-YL) - HETEROARYLOXY] - (1-AZA-BICYCLO [3.3.1] NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENRATIVE DISORDERS | CHRNA5, CHRNA7, CHRNA6 | CHRM1 20/4885CHRM2 25/4885HMOX1 1946/4885 |
| US-20100179160-A1 | ORGANIC COMPOUNDS | TPMT, DNMT1, DNMT3L | CHRM1 1313/4885CHRM2 1798/4885HMOX1 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.