Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173219 | 0.98 | GSK3B (0.38) | GSK3BKDM4ESMN1; SMN2CYP1A2SIGMAR1 | |
| SCHEMBL4173220 | 0.91 | SIGMAR1 (0.34) | GSK3BKDM4ESIGMAR1PDE4APDE4B | |
| SCHEMBL4172778 | 0.89 | ADRB2 (0.38) | KDM4ESMN1; SMN2CYP1A2SIGMAR1PDE4A | |
| SCHEMBL4183936 | 0.83 | SIGMAR1 (0.37) | GSK3BKDM4ESIGMAR1P2RY14ATR | |
| SCHEMBL4186330 | 0.83 | SIGMAR1 (0.36) | GSK3BKDM4ESIGMAR1P2RY14CA1 | |
| SCHEMBL4183931 | 0.82 | SIGMAR1 (0.37) | GSK3BKDM4ESIGMAR1P2RY14ATR | |
| SCHEMBL4886270 | 0.81 | KDM4E (0.43) | GSK3BKDM4ESMN1; SMN2CYP1A2ALDH1A1 | |
| SCHEMBL4169255 | 0.81 | SIGMAR1 (0.38) | GSK3BSIGMAR1P2RY14ATRATRIP | |
| SCHEMBL4186321 | 0.81 | SIGMAR1 (0.36) | GSK3BKDM4ESIGMAR1P2RY14MEN1 | |
| SCHEMBL5433734 | 0.80 | SIGMAR1 (0.40) | GSK3BKDM4ESMN1; SMN2CYP1A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | GSK3B 2763/4885KDM4E 3897/4885SMN1; SMN2 2560/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | GSK3B 3177/4885KDM4E 4136/4885SMN1; SMN2 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.