SCHEMBL417331

SCHEMBL417331

Nc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc(N)c1N1CCOCC1

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.60
KCNH2 Q12809 1/20 0.60
GUCY1A1 Q02108 10/20 0.51
GUCY1B1 Q02153 10/20 0.51
PDE5A O76074 8/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382996 1.00 ADORA3 (0.60) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL15087585 0.94 ADORA3 (0.58) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL10252555 0.91 ADORA3 (0.62) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL174847 0.86 ADORA3 (0.67) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL23162011 0.86 ADORA3 (0.43) ADORA3KCNH2GUCY1A1GUCY1B1
Hydrochloric Acid SCHEMBL1930775 0.85 ADORA3 (0.66) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Hydrochloric Acid SCHEMBL18496411 0.85 ADORA3 (0.66) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL255832 0.85 ADORA3 (0.57) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL458874 0.84 ADORA3 (0.57) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL2365288 0.84 PDE5A (0.50) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 402 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250387391-A1 A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION UNIV BERLIN CHARITE (DE) 2025-12-25 US claimed
US-20250281485-A1 DIAGNOSIS AND/OR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION UNIVERSITEIT MAASTRICHT (NL) 2025-09-11 US claimed
EP-4511017-A1 DIAGNOSIS AND/OR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION Universiteit Maastricht (NL) 2025-02-26 EP claimed
CN-119367341-A Methods of treating PAH using RALINEPAG in combination with other agents 阿瑞那制药公司 2025-01-28 CN claimed
EP-4472620-A1 A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION Charité - Universitätsmedizin Berlin (DE) 2024-12-11 EP claimed
WO-2023204698-A1 DIAGNOSIS AND/OR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION UNIVERSITEIT MAASTRICHT (NL) 2023-10-26 WO claimed
CN-116726178-A Use of sGC stimulators in the treatment of non-alcoholic steatohepatitis (NASH) 赛克里翁治疗有限公司 2023-09-12 CN claimed
EP-4233851-A1 A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION Charité - Universitätsmedizin Berlin (DE) 2023-08-30 EP claimed
WO-2023148203-A1 A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN (DE) 2023-08-10 WO claimed
EP-4087469-A1 DEVICES AND METHODS FOR TREATING CANCER AND CARDIAC WASTING Nazzano Devices Limited (IE) 2022-11-16 EP claimed
WO-2010081647-A2 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-07-22 WO claimed
EP-2144605-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS Bayer HealthCare AG (DE) 2010-01-20 EP claimed
WO-2009138165-A1 SGC STIMULATORS, SGC ACTIVATORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF HEARING IMPAIRMENT BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-11-19 WO claimed
WO-2008138483-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-11-20 WO claimed
US-20050181066-A1 Novel use of guanylate cyclase activators for the treatment of respiratory insufficiency ALTANA PHARMA AG (DE) 2005-08-18 US claimed
US-20050059660-A1 activators of soluble guanylate cyclase, and inhibitors of angiotensin converting enzyme such as benazepril; treatment of cardiovascular or metabolic disorders PHARMACIA & UPJOHN COMPANY 2005-03-17 US claimed
WO-2005011727-A1 COMBINATION OF AN ACTIVATOR OF SOLUBLE GUANYLATE CYCLASE AND AN ACE-INHIBITOR FOR THE TREATMENT OF A CARDIOVASCULAR OR METABOLIC DISORDER PFIZER LIMITED (GB) 2005-02-10 WO claimed
EP-1501605-A1 NOVEL USE OF GUANYLATE CYCLASE ACTIVATORS FOR THE TREATMENT OF RESPIRATORY INSUFFICIENCY ALTANA Pharma AG (DE) 2005-02-02 EP claimed
WO-2003090870-A1 NOVEL USE OF GUANYLATE CYCLASE ACTIVATORS FOR THE TREATMENT OF RESPIRATORY INSUFFICIENCY ALTANA PHARMA AG (DE) 2003-11-06 WO claimed
WO-2001047494-A1 METHOD FOR CO-GRINDING SUBSTANCES AND LACTOSE BY MEANS OF JET MILS BAYER AKTIENGESELLSCHAFT (DE) 2001-07-05 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250387391-A1 A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION GUCY1A1, PDE3B, PDE2A ADORA3 1654/4885KCNH2 913/4885GUCY1A1 1/4885
US-20250281485-A1 DIAGNOSIS AND/OR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION NOX5, PDE5A, NOX1 ADORA3 3645/4885KCNH2 1680/4885GUCY1A1 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.