Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.37 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3144654 | 0.99 | NAMPT (0.39) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| SCHEMBL15016176 | 0.92 | CHRM1 (0.41) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| Hydrochloric Acid SCHEMBL3144690 | 0.92 | CHRM1 (0.41) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| SCHEMBL15016228 | 0.91 | NAMPT (0.40) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| Hydrochloric Acid SCHEMBL3144075 | 0.90 | NAMPT (0.39) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| SCHEMBL15016286 | 0.90 | CXCR3 (0.41) | ITGB3ITGA2BROCK2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3157630 | 0.89 | CXCR3 (0.41) | ITGB3ITGA2BROCK2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3153797 | 0.89 | LMNA (0.42) | ITGB3ITGA2BROCK2MEN1KMT2A | |
| SCHEMBL15016272 | 0.89 | BRD4 (0.39) | NAMPTITGB3ITGA2BROCK2MEN1 | |
| Hydrochloric Acid SCHEMBL3143538 | 0.88 | MEN1 (0.39) | NAMPTITGB3ITGA2BROCK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074083-B1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2013-06-19 | — | — | EP | claimed |
| EP-2074083-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-07-01 | — | — | EP | claimed |
| WO-2008050168-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | claimed |