SCHEMBL4173580

SCHEMBL4173580

O=C1O[C@H](CCS(=O)(=O)O)CN1c1ccc(-c2ccc(N3CCN(Cc4ccc([N+](=O)[O-])o4)CC3)c(F)c2)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.42
POLB P06746 1/20 0.41
CALML3 P27482 7/20 0.41
MAOA P21397 3/20 0.40
LMNA P02545 1/20 0.40
PTGS1 P23219 1/20 0.40
SDHA P31040 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4173592 1.00 MAOB (0.42) MAOBPOLBCALML3MAOALMNA
SCHEMBL4173585 1.00 MAOB (0.42) MAOBPOLBCALML3MAOALMNA
SCHEMBL14566846 0.87 MAOB (0.45) MAOBPOLBCALML3MAOALMNA
SCHEMBL4760664 0.86 POLB (0.45) MAOBPOLBCALML3MAOALMNA
SCHEMBL4173403 0.86 MAOA (0.58) MAOBCALML3MAOALMNAPTGS1
SCHEMBL4173405 0.86 MAOA (0.58) MAOBCALML3MAOALMNAPTGS1
SCHEMBL4176992 0.83 CALML3 (0.51) MAOBCALML3MAOALMNAPTGS1
SCHEMBL4176996 0.83 CALML3 (0.51) MAOBCALML3MAOALMNAPTGS1
SCHEMBL5808132 0.82 POLB (0.50) MAOBPOLBCALML3MAOALMNA
SCHEMBL4170735 0.81 CALML3 (0.49) MAOBCALML3MAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US claimed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT MAOB 3240/4885POLB 4/4885CALML3 4576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.