Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082535 | 0.85 | HPGD (0.60) | HPGDTHRBKMT2AALDH1A1LMNA | |
| SCHEMBL31659577 | 0.84 | THRB (0.60) | HPGDTHRBKMT2AALDH1A1LMNA | |
| SCHEMBL2234130 | 0.82 | HPGD (1.00) | HPGDTHRBKMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28152221 | 0.80 | HPGD (0.97) | HPGDTHRBKMT2AALDH1A1LMNA | |
| SCHEMBL25328235 | 0.80 | THRB (0.77) | THRBKMT2AALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL28820363 | 0.80 | ALDH1A1 (0.60) | HPGDTHRBKMT2AALDH1A1LMNA | |
| SCHEMBL19028142 | 0.79 | TSHR (0.76) | HPGDTHRBKMT2ALMNATSHR | |
| SCHEMBL3475021 | 0.77 | ALDH1A1 (0.57) | HPGDTHRBKMT2AALDH1A1LMNA | |
| SCHEMBL7082686 | 0.77 | TSHR (0.73) | THRBKMT2AALDH1A1LMNATSHR | |
| SCHEMBL14415899 | 0.76 | THRB (0.77) | THRBKMT2AALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084470-B2 | Substituted nicotinamide compounds and uses thereof | GRUENENTHAL GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| US-20090076086-A1 | SUBSTITUTED NICOTINAMIDE COMPOUNDS AND USES THEREOF | GRUENENTHAL GMBH (DE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076086-A1 | SUBSTITUTED NICOTINAMIDE COMPOUNDS AND USES THEREOF | NNT, NAMPT, NADK | HPGD 11/4885THRB 3911/4885KMT2A 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.