Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.48 |
| ▸ | TUBB | P07437 | 3/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178548 | 0.90 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4181693 | 0.84 | FYN (0.41) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4181716 | 0.81 | TUBB4A (0.68) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4173256 | 0.78 | KDR (0.66) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4188216 | 0.77 | FYN (0.48) | ALDH1A1MAPTKDRCLK4CLK1 | |
| SCHEMBL13605665 | 0.73 | FYN (0.47) | ALDH1A1GAAMAPTCLK1MAPK1 | |
| SCHEMBL4170609 | 0.73 | TUBB4A (0.67) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4167669 | 0.73 | KDR (0.51) | ALDH1A1KDM4EGAAMAPTKDR | |
| SCHEMBL4174196 | 0.72 | KDM4E (0.37) | ALDH1A1KDM4EKDRCLK4CYP3A4 | |
| SCHEMBL4185165 | 0.72 | KDR (0.70) | ALDH1A1KDM4EGAAMAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2005004818-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | TP53, MCL1, VHL | ALDH1A1 535/4885KDM4E 2144/4885GAA 203/4885 |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | TP53, MCL1, VHL | ALDH1A1 535/4885KDM4E 2144/4885GAA 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.