Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | SDHB | P21912 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167348 | 0.86 | NR1H2 (0.41) | NR1H2NR1H3PTPN1MEN1S1PR4 | |
| SCHEMBL27786940 | 0.84 | NR1H2 (0.42) | NR1H2NR1H3PIK3CDMEN1S1PR4 | |
| SCHEMBL4174648 | 0.83 | NR1H2 (0.46) | NR1H2NR1H3PTPN1MEN1POLB | |
| SCHEMBL4160610 | 0.80 | NR1H2 (0.40) | NR1H2NR1H3PPARGLMNAHPGD | |
| SCHEMBL4165443 | 0.78 | NR1H2 (0.44) | NR1H2NR1H3PTPN1PIK3CDESR1 | |
| SCHEMBL4156275 | 0.78 | PTGS2 (0.39) | NR1H2NR1H3PTPN1MEN1S1PR4 | |
| SCHEMBL4174099 | 0.76 | PTGS2 (0.41) | NR1H2NR1H3MEN1S1PR4LMNA | |
| SCHEMBL4165744 | 0.74 | PARP1 (0.44) | NR1H2NR1H3PPARGLMNAHPGD | |
| SCHEMBL27796472 | 0.73 | DPP4 (0.41) | NR1H2NR1H3MEN1S1PR4LMNA | |
| SCHEMBL4167355 | 0.72 | NR1H2 (0.44) | NR1H2NR1H3PTPN1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |