Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SDHB | P21912 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765248 | 0.88 | NR1H2 (0.40) | PTGS2NR1H2NR1H3ESR1KMO | |
| SCHEMBL4164422 | 0.87 | NR1H2 (0.38) | PTGS2NR1H2NR1H3ESR1KMO | |
| SCHEMBL4167348 | 0.82 | NR1H2 (0.41) | PTGS2LMNANPSR1SDHBMEN1 | |
| SCHEMBL27786915 | 0.81 | ESR1 (0.40) | MAPK1HSD17B10NR1H2NR1H3ESR1 | |
| SCHEMBL27786940 | 0.80 | NR1H2 (0.42) | LMNANPSR1SDHBMEN1S1PR4 | |
| SCHEMBL4156275 | 0.80 | PTGS2 (0.39) | PTGS2LMNANPSR1SDHBMEN1 | |
| SCHEMBL27765196 | 0.79 | PTGS2 (0.64) | PTGS2LMNANPSR1MEN1TP53 | |
| SCHEMBL4174108 | 0.79 | NR1H3 (0.46) | LMNANPSR1SDHBMEN1S1PR4 | |
| SCHEMBL27765478 | 0.78 | NR1H2 (0.37) | LMNANPSR1SDHBMEN1S1PR4 | |
| SCHEMBL28780680 | 0.78 | P2RX7 (0.37) | LMNANPSR1SDHBMEN1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | claimed |
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |