Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459786 | 0.83 | HDAC1 (0.52) | HDAC1HDAC8HDAC6SLC40A1SMN1; SMN2 | |
| SCHEMBL26978028 | 0.82 | HDAC1 (0.42) | HDAC1HDAC8HDAC6SLC40A1HTR2B | |
| SCHEMBL14440725 | 0.79 | TLR7 (0.48) | HDAC1HDAC8HDAC6SLC40A1SMN1; SMN2 | |
| SCHEMBL4673108 | 0.79 | HDAC1 (0.42) | HDAC1HDAC8HDAC6SLC40A1SMN1; SMN2 | |
| SCHEMBL4673105 | 0.79 | HDAC1 (0.42) | HDAC1HDAC8HDAC6SLC40A1SMN1; SMN2 | |
| SCHEMBL15651710 | 0.79 | HDAC1 (0.68) | HDAC1HDAC8HDAC6HTR2BACHE | |
| SCHEMBL4447353 | 0.77 | L3MBTL1 (0.47) | SMN1; SMN2ALDH1A1L3MBTL1RAB9ALMNA | |
| SCHEMBL28291566 | 0.74 | PDE10A (0.50) | SMN1; SMN2ALDH1A1L3MBTL1KMT2ARAB9A | |
| SCHEMBL3800903 | 0.72 | CDK5 (0.56) | HDAC1HDAC8HDAC6HTR2BSMN1; SMN2 | |
| SCHEMBL28211956 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2PARP10ALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069320-A1 | Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof | GRUENENTHAL GMBH (DE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069320-A1 | Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof | GRM1, GRIN1, GRM2 | HDAC1 1079/4885HDAC8 850/4885HDAC6 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.