SCHEMBL4174859

SCHEMBL4174859

O=C(NCC1CN(c2cc(F)c(N3CCC(n4cnnn4)CC3)c(F)c2)C(=O)O1)C(F)F

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.42
MAOA P21397 5/20 0.41
LMNA P02545 1/20 0.41
PTGS1 P23219 1/20 0.41
CALML3 P27482 1/20 0.41
SDHA P31040 1/20 0.41
F10 P00742 11/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4174854 1.00 MAOB (0.42) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4174135 0.91 MAOB (0.40) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4174141 0.91 MAOB (0.40) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4177073 0.90 MAOA (0.52) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4181753 0.90 MAOA (0.52) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4162995 0.89 MAOB (0.54) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4162993 0.89 MAOB (0.54) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4158414 0.88 MAOA (0.42) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4160628 0.88 MAOA (0.42) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4163662 0.88 MAOA (0.43) MAOBMAOALMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP disclosed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT MAOB 3240/4885MAOA 3788/4885LMNA 1529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.