Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31185924 | 0.86 | PDE3B (0.53) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL4881234 | 0.83 | ALDH1A1 (0.73) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL18796630 | 0.77 | PDE3B (0.80) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL18044655 | 0.76 | GAA (0.62) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL78402 | 0.76 | MAPT (0.55) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL10746820 | 0.76 | KDM4E (0.53) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL9672980 | 0.76 | ALDH1A1 (0.88) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL18796647 | 0.75 | PDE3B (0.69) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL18796637 | 0.75 | PDE3B (0.76) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL5056804 | 0.75 | ALDH1A1 (0.61) | PDE3BPDE3AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | P2RY12, P2RY11, P2RY1 | PDE3B 243/4885PDE3A 504/4885MAPT 3645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.