Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881234 | 0.90 | ALDH1A1 (0.73) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL612717 | 0.86 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL18395324 | 0.80 | TSHR (0.50) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL9671945 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL4175783 | 0.75 | PDE3B (0.60) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL4876345 | 0.74 | ALDH1A1 (0.76) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL3593126 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL950017 | 0.73 | ALDH1A1 (0.73) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL4871436 | 0.73 | GAA (1.00) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL18796672 | 0.73 | PDE3B (0.73) | ALDH1A1MAPTLMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |