Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 7/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121558 | 0.90 | SLC18A3 (0.56) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL3120519 | 0.90 | SLC18A3 (0.56) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL3120525 | 0.90 | SLC18A3 (0.56) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL2965273 | 0.87 | SLC18A3 (0.81) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL30563652 | 0.83 | SLC18A3 (0.96) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| Cyanide SCHEMBL27976792 | 0.81 | SLC18A3 (0.73) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL7888827 | 0.81 | SLC18A3 (1.00) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL11121512 | 0.81 | SLC18A3 (1.00) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL206905 | 0.80 | SLC18A3 (0.54) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7879553 | 0.80 | SLC18A3 (0.96) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | AMGEN INC. (US) | 2009-09-10 | — | — | US | claimed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | claimed |
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | AMGEN INC. (US) | 2009-09-10 | — | — | US | disclosed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | BDKRB1, BDKRB2, VIPR1 | SLC18A3 1092/4885GRIN2B 471/4885CYP2D6 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.