Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.48 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MCOLN2 | Q8IZK6 | 2/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.41 |
| ▸ | MCOLN1 | Q9GZU1 | 2/20 | 0.41 |
| ▸ | PPIB | P23284 | 2/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.41 |
| ▸ | PPIG | Q13427 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4179996 | 0.86 | SCN9A (0.51) | SCN9ASCD5TRPC3TRPC6ROCK2 | |
| SCHEMBL4177686 | 0.86 | SCN9A (0.51) | SCN9ATRPC3TRPC6HSP90AA1HSP90AB1 | |
| SCHEMBL4172599 | 0.85 | TRPC3 (0.61) | SCN9ASCD5TRPC3TRPC6TRPV1 | |
| SCHEMBL4176998 | 0.84 | TRPC3 (0.52) | SCN9ASCD5TRPC3TRPC6ROCK2 | |
| SCHEMBL4177448 | 0.83 | TRPC3 (0.54) | SCN9ATRPC3TRPC6HSP90AA1HSP90AB1 | |
| SCHEMBL4165105 | 0.82 | TRPC3 (0.66) | SCN9ASCD5TRPC3TRPC6ALDH1A1 | |
| SCHEMBL4170692 | 0.82 | TRPC3 (0.65) | SCN9ASCD5TRPC3TRPC6ALDH1A1 | |
| SCHEMBL4173881 | 0.81 | TRPC3 (0.56) | SCN9ASCD5TRPC3TRPC6ROCK2 | |
| SCHEMBL4180201 | 0.81 | SCN9A (0.49) | SCN9ASCD5TRPC3TRPC6KDM1A | |
| SCHEMBL4165060 | 0.81 | TRPC3 (0.55) | SCN9ASCD5TRPC3TRPC6ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | SCN9A 51/4885SCD5 1301/4885TRPC3 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.