Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.41 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31507494 | 0.73 | L3MBTL1 (0.40) | GRM5 | |
| SCHEMBL21066336 | 0.72 | L3MBTL1 (0.54) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL8834236 | 0.71 | L3MBTL1 (0.63) | SMN1; SMN2RAB9AATAD2NPC1ALDH1A1 | |
| SCHEMBL689416 | 0.70 | L3MBTL1 (0.72) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL7136797 | 0.70 | L3MBTL1 (0.49) | SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL26979851 | 0.69 | HTR2B (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7868159 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9AATAD2GRM5ALDH1A1 | |
| SCHEMBL14543340 | 0.68 | HTR2B (0.45) | RAB9ANPC1ALDH1A1MAPTLMNA | |
| SCHEMBL27792064 | 0.68 | L3MBTL1 (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL16397272 | 0.67 | ACHE (0.54) | SMN1; SMN2RAB9ANPC1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | SMN1; SMN2 3959/4885GLS 4192/4885RAB9A 3958/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | SMN1; SMN2 3959/4885GLS 4192/4885RAB9A 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.