Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207598 | 0.80 | MAPT (0.46) | KDM4EMAPTCYP3A4MAPK1HSD17B10 | |
| SCHEMBL10336692 | 0.78 | MAPT (0.45) | KDM4EMAPTCYP3A4MAPK1HSD17B10 | |
| SCHEMBL1491049 | 0.77 | CA2 (0.36) | KDM4EMAPTCYP3A4HSD17B10TP53 | |
| SCHEMBL22833910 | 0.77 | MAPT (0.43) | KDM4EMAPTCYP3A4MAPK1HSD17B10 | |
| SCHEMBL5209906 | 0.77 | TP53 (0.43) | KDM4EMAPTCYP3A4MAPK1HSD17B10 | |
| SCHEMBL315821 | 0.76 | ACHE (0.39) | KDM4EMAPTCYP3A4MAPK1ALDH1A1 | |
| SCHEMBL10771504 | 0.74 | TP53 (0.37) | KDM4EMAPTCYP3A4MAPK1HSD17B10 | |
| SCHEMBL4438400 | 0.72 | — | — | |
| SCHEMBL2353186 | 0.72 | — | — | |
| SCHEMBL10447228 | 0.71 | MAPT (0.38) | KDM4EMAPTCYP3A4MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099167-A1 | Organic compounds | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH | 2009-04-16 | — | — | US | disclosed |
| US-20090069315-A1 | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders | SIVASANKARAN RAJEEV | 2009-03-12 | — | — | US | disclosed |
| US-20050222171-A1 | Organic compounds | NOVARTIS AG (CH) | 2005-10-06 | — | — | US | disclosed |
| US-5206360-A | Bactericides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| US-5169843-A | Bactericides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0484030-A2 | Antibiotic C-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof | Bristol-Myers Squibb Company (US) | 1992-05-06 | — | — | EP | disclosed |
| US-5106842-A | Bactericides | BRISTOL-MYERS SQUIBB CO. (US) | 1992-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069315-A1 | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders | EPHA5, EPHA7, EPHA1 | KDM4E 2164/4885MAPT 582/4885CYP3A4 3606/4885 |
| US-20050222171-A1 | Organic compounds | JAK1, MAP3K5, MAP3K7 | KDM4E 1049/4885MAPT 793/4885CYP3A4 933/4885 |
| US-20090099167-A1 | Organic compounds | JAK1, MAP3K5, MAP3K7 | KDM4E 1049/4885MAPT 793/4885CYP3A4 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.