SCHEMBL4176984

SCHEMBL4176984

CC(=O)NCC1CN(c2ccc(-c3ccc(N4CCC(O)(COC(C)=O)CC4)nc3)c(F)c2)C(=O)O1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOA P21397 7/20 0.54
CALML3 P27482 4/20 0.51
MAOB P27338 3/20 0.51
PTGS1 P23219 2/20 0.51
SDHA P31040 2/20 0.51
LMNA P02545 1/20 0.51
CYP3A4 P08684 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4176982 1.00 MAOA (0.54) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4169074 0.93 MAOA (0.54) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4169080 0.93 MAOA (0.54) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4162986 0.87 MAOA (0.57) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4162982 0.87 MAOA (0.57) MAOACALML3MAOBPTGS1SDHA
SCHEMBL6798565 0.86 MAOA (0.54) MAOACALML3MAOBPTGS1SDHA
SCHEMBL6798606 0.86 MAOA (0.54) MAOACALML3MAOBPTGS1SDHA
SCHEMBL6624387 0.86 MAOA (0.57) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4171585 0.85 MAOA (0.61) MAOACALML3MAOBPTGS1SDHA
SCHEMBL4171562 0.85 MAOA (0.61) MAOACALML3MAOBPTGS1SDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US claimed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP disclosed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT MAOA 3788/4885CALML3 4576/4885MAOB 3240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.