SCHEMBL4177355

SCHEMBL4177355

NN(C(=O)CS)C(=O)CS

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3905538 0.67
SCHEMBL9052467 0.67 TSHR (0.39) TSHR
SCHEMBL717592 0.67 TSHR (0.36) TSHRHSD17B10
Hydrochloric Acid SCHEMBL10683777 0.65
SCHEMBL3905585 0.63
SCHEMBL7522331 0.63 TSHR (0.33) TSHRHSD17B10
SCHEMBL8766 0.62
SCHEMBL13572157 0.60
SCHEMBL9492808 0.60
SCHEMBL13572269 0.60

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3908286-A1 NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF Singular Genomics Systems, Inc. (US) 2021-11-17 EP disclosed
WO-2020146397-A1 NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF Singular Genomics Systems, Inc. (US) 2020-07-16 WO disclosed
CN-110506121-A The cutting reagent of sulfur-bearing hydroxyl and oxidation rinsing agent INTELLIGENT BIO SYSTEMS INC 2019-11-26 CN disclosed
EP-3535407-A1 THIOL-CONTAINING CLEAVE REAGENTS AND OXIDATIVE WASH Qiagen Sciences, LLC (US) 2019-09-11 EP disclosed
CN-110168346-A Multiplex imaging using MERISH, extended microscopy and related techniques 哈佛学院院长及董事 2019-08-23 CN disclosed
CN-110140175-A Matrix imprinting and clearance 哈佛学院院长及董事 2019-08-16 CN disclosed
CN-109476694-A Nucleotide analog 奇根科学有限责任公司 2019-03-15 CN disclosed
CN-107001460-A Selective reduction of cysteine residues in Il-17 antibodies 诺华股份有限公司 2017-08-01 CN disclosed
CN-106715768-A System and method for assaying nucleic acids 哈佛学院院长及董事 2017-05-24 CN disclosed
US-9371521-B2 Substituted pyrazinedithiol reducing agents WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2016-06-21 US disclosed
US-7163932-B2 Aryldifluoromethylphosphonic acids for treatment of diabetes MERCK FROSST CANADA & CO. (CA) 2007-01-16 US disclosed
EP-1558283-A2 HCV VACCINE COMPOSITIONS COMPRISING E1 AND NS3 PEPTIDES INNOGENETICS N.V. (BE) 2005-08-03 EP disclosed
WO-2004041853-A2 HCV VACCINE COMPOSITIONS COMPRISING E1 AND NS3 PEPTIDES INNOGENETICS N.V. (BE) 2004-05-21 WO disclosed
EP-0888543-A4 AZATIDE PEPTIDOMIMETICS SCRIPPS RESEARCH INST (US) 2004-04-07 EP disclosed
US-6465444-B2 PROTEIN TYROSINE PHOSPHATASES(PTP-1B); ANTIDIABETIC, ANTITUMOR AND ANOREXIGENIC AGENTS; COMBINATION THERAPY MERCK FROSST CANADA & CO. 2002-10-15 US disclosed
EP-0888543-A1 AZATIDE PEPTIDOMIMETICS The Scripps Research Institute (US) 1999-01-07 EP disclosed
WO-1997035199-A9 AZATIDE PEPTIDOMIMETICS 1997-12-11 WO disclosed
WO-1997035199-A1 AZATIDE PEPTIDOMIMETICS THE SCRIPPS RESEARCH INSTITUTE (US) 1997-09-25 WO disclosed
WO-1996040107-A1 THE USE OF N,N'-BIS(MERCAPTOACETYL) HYDRAZINE DRIVATIVES AS ANTICATARACT AGENTS ALCON LABORATORIES, INC. (US) 1996-12-19 WO disclosed
WO-1993021303-A2 ENHANCED PURIFICATION AND EXPRESSION OF INSOLUBLE RECOMBINANT PROTEINS CHIRON CORPORATION (US) 1993-10-28 WO disclosed