Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528068 | 0.83 | NPC1 (0.67) | SMN1; SMN2RAB9ANPC1POLBNUDT1 | |
| SCHEMBL7363505 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1POLBNUDT1 | |
| SCHEMBL4528036 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1NUDT1KMT2A | |
| SCHEMBL2902967 | 0.73 | HTT (0.53) | SMN1; SMN2POLBKMT2AMEN1MAPT | |
| SCHEMBL4535234 | 0.72 | CYP1A2 (0.57) | SMN1; SMN2RAB9ANPC1NUDT1KMT2A | |
| SCHEMBL754480 | 0.70 | NUDT1 (0.61) | SMN1; SMN2RAB9ANPC1POLBNUDT1 | |
| SCHEMBL11972460 | 0.69 | F10 (0.58) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL10720328 | 0.69 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1POLBNUDT1 | |
| SCHEMBL21186284 | 0.69 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1POLBKMT2A | |
| SCHEMBL2334140 | 0.69 | IGF1R (0.40) | RAB9ANPC1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082404-A1 | BENZIMIDAZOLES | MERCK PATENT GMBH (DE) | 2009-03-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082404-A1 | BENZIMIDAZOLES | TIE1, KDR, FLT1 | SMN1; SMN2 2539/4885RAB9A 3539/4885NPC1 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.