Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707234 | 0.98 | MAPT (0.56) | MAPTKCNH2GPR84HCAR2HIF1A | |
| SCHEMBL12326067 | 0.94 | MAPT (0.51) | MAPTKCNH2GPR84KMT2AHCAR2 | |
| SCHEMBL8481242 | 0.86 | MAPT (0.46) | MAPTKMT2AMEN1LMNA | |
| SCHEMBL8800522 | 0.79 | MAPT (0.41) | MAPTKMT2AMEN1LMNA | |
| SCHEMBL10844761 | 0.78 | MAPT (0.42) | MAPTGPR84KMT2AMEN1LMNA | |
| SCHEMBL10844766 | 0.78 | MAPT (0.42) | MAPTGPR84KMT2AMEN1LMNA | |
| SCHEMBL1809844 | 0.73 | POLB (0.38) | MAPTKMT2AMEN1LMNA | |
| SCHEMBL1806488 | 0.71 | POLB (0.39) | MAPTKMT2AMEN1LMNA | |
| SCHEMBL45208 | 0.71 | KCNH2 (0.48) | MAPTKCNH2GPR84HCAR2HCAR3 | |
| SCHEMBL5174532 | 0.71 | MAPT (0.57) | MAPTGPR84KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553174-B1 | ARYLPYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1998-07-08 | — | — | EP | claimed |
| US-5376656-A | Arylpyridazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-12-27 | — | — | US | claimed |
| EP-0553174-A1 | ARYLPYRIDAZINONES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-08-04 | — | — | EP | claimed |
| WO-1992006963-A1 | ARYLPYRIDAZINONES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1992-04-30 | — | — | WO | claimed |
| US-4707481-A | Pyridazinones, their preparation and use, and bronchospasmolytic medicaments containing pyridazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-11-17 | — | — | US | claimed |
| EP-0125636-B1 | PYRIDAZINONES, THEIR PREPARATION AND USE, MEDICINES CONTAINING THESE PYRIDAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1987-04-01 | — | — | EP | claimed |
| EP-0141847-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | claimed |
| WO-1984004521-A1 | PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | claimed |
| WO-1984004522-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | claimed |
| EP-0125636-A1 | Pyridazinones, their preparation and use, medicines containing these pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-11-21 | — | — | EP | claimed |
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | claimed |
| EP-0010156-B1 | 6-ARYLPYRIDAZINE-3-ONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MERCK PATENT GmbH (DE) | 1982-10-06 | — | — | EP | claimed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | claimed |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-7531540-B2 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2009-05-12 | — | — | US | disclosed |
| CN-101410120-A | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES INC (US) | 2009-04-15 | — | — | CN | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |
| US-4193941-A | INTERMEDIATES FOR 6-(2-HYDROXPHENYL)-3-PYRIDAZINONES | SMITHKLINE CORPORATION (US) | 1980-03-18 | — | — | US | disclosed |
| US-4189578-A | CHEMICAL INTERMEDIATES FOR HYPOTENSIVE AGENTS | SMITHKLINE CORPORATION (US) | 1980-02-19 | — | — | US | disclosed |
| US-4092311-A | Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates | AMERICAN CYANAMID COMPANY (US) | 1978-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | MAPT 2574/4885KCNH2 4556/4885GPR84 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.