Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxybate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.48 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.48 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.88 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.68 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxybate SCHEMBL10786 | 0.94 | — | — | |
| Oxybate SCHEMBL1124035 | 0.94 | CAMK2A (1.00) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL29059444 | 0.94 | CAMK2A (1.00) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| 1,3-Propanediol SCHEMBL29216017 | 0.90 | CAMK2A (0.71) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL23701412 | 0.90 | — | — | |
| Oxybate SCHEMBL5668354 | 0.90 | — | — | |
| Oxybate SCHEMBL18260136 | 0.90 | CAMK2A (0.93) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL20551245 | 0.90 | — | — | |
| Oxybate SCHEMBL408934 | 0.90 | — | — | |
| Oxybate SCHEMBL5668295 | 0.90 | CAMK2A (0.93) | CAMK2AGPR84FFAR1FFAR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116564413-A | Method for detecting microorganism types and abundance of different carbon fixation paths | 中国海洋大学 | 2023-08-08 | — | — | CN | claimed |
| CN-116564413-A | Method for detecting microorganism types and abundance of different carbon fixation paths | 中国海洋大学 | 2023-08-08 | — | — | CN | disclosed |
| WO-2023118140-A1 | CARBON FIXATION SYSTEM | PHASE BIOLABS LTD (GB) | 2023-06-29 | — | — | WO | disclosed |
| CN-115960720-A | Microorganisms and methods for producing fatty alcohols of specific length and related compounds | 基因组股份公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-115851850-A | Method for preparing starch by using carbon dioxide, recombinant microorganism and method for constructing recombinant microorganism | 中国科学院天津工业生物技术研究所 | 2023-03-28 | — | — | CN | disclosed |
| CN-104884629-B | Microorganisms and methods for producing fatty alcohols of specific length and related compounds | 基因组股份公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-107002019-B | Recombinant yeast producing 3-hydroxypropionic acid and method for producing 3-hydroxypropionic acid using same | SK新技术株式会社 | 2021-11-23 | — | — | CN | disclosed |
| EP-2880155-B1 | USE OF THE REDUCTIVE GLYCINE PATHWAY FOR GENERATING FORMATOTROPHIC AND AUTOTROPHIC MICROORGANISMS | YEDA RES & DEV (IL) | 2019-04-17 | — | — | EP | disclosed |
| EP-1514897-B1 | A STABILIZER AGAINST HYDROLYSIS FOR AN ESTER-GROUP- CONTAINING RESIN AND A THERMOPLASTIC RESIN COMPOSITION | NISSHIN SPINNING (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20130288317-A1 | INCREASED YIELDS OF PHAS FROM HYDROGEN FEEDING AND DIVERSE CARBON FIXATION PATHWAYS | METABOLIX, INC. | 2013-10-31 | — | — | US | disclosed |
| US-20090023182-A1 | COMPLEMENTARY METABOLIZING ORGANISMS AND METHODS OF MAKING SAME | GENOMATICA, INC. | 2009-01-22 | — | — | US | disclosed |