Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxybate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.53 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 1.00 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.77 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.77 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxybate SCHEMBL10786 | 1.00 | — | — | |
| Oxybate SCHEMBL29059444 | 1.00 | CAMK2A (1.00) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL5566577 | 0.97 | — | — | |
| Oxybate SCHEMBL5668295 | 0.97 | CAMK2A (0.93) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL408934 | 0.97 | — | — | |
| Oxybate SCHEMBL23701412 | 0.97 | — | — | |
| Oxybate SCHEMBL18260136 | 0.97 | CAMK2A (0.93) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL18260134 | 0.97 | CAMK2A (0.93) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Oxybate SCHEMBL20551245 | 0.97 | — | — | |
| Oxybate SCHEMBL5668354 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250152601-A1 | Compositions and Methods for the Treatment of Sexual Dysfunctions | THE JONATHAN HURT LIVING TRUST (US) | 2025-05-15 | — | — | US | disclosed |
| CN-118879602-A | Methods and organisms with increased carbon flux efficiency | 基因组股份公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-113416686-B | Methods and organisms with increased carbon flux efficiency | 基因组股份公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-117980472-A | Formate dehydrogenase variants and methods of use | 基因组股份公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115322261-A | Methanol dehydrogenase fusion protein | 基因组股份公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-108779153-B | Methanol dehydrogenase fusion proteins | 基因组股份公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114514035-A | Compositions and methods for delivering therapeutic biologies for treatment of diseases | 伊勒卓菲公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-104685058-B | Microorganisms and methods for making 4-hydroxybutyrate, 1, 4-butanediol, and related compounds | 基因组股份公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-107014939-B | The method that ion exclusion-ion exchange column switching combination measures the gamma-hydroxybutyric acid in urine | 南京市公安局刑事侦查局 | 2018-06-08 | — | — | CN | disclosed |
| CN-107014939-A | The method that the switching combination of ion exclusion ion exchange column determines the γ hydroxybutyric acids in urine | 南京市公安局刑事侦查局 | 2017-08-04 | — | — | CN | disclosed |
| CN-106474933-A | The preparation method of hollow fiber ultrafiltration membrane | 河南华禹环保科技有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-102762735-B | Microorganisms producing 1, 4-butanediol, 4-hydroxybutyraldehyde, 4-hydroxybutyryl-COA, putrescine and related compounds and related methods | 基因组股份公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105441374-A | Microorganism for producing 1, 4-butanediol, 4-hydroxybutyraldehyde, 4-maloyl-COA, putrescine and related compound and related method thereof | GENOMATICA INC | 2016-03-30 | — | — | CN | disclosed |
| WO-2011132171-A1 | NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-10-27 | — | — | WO | disclosed |
| US-20110263526-A1 | Nitric Oxide Releasing Prodrugs of Therapeutic Agents | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-10-27 | — | — | US | disclosed |
| US-20110104768-A1 | METHOD FOR PRODUCTION OF POLYESTER COPOLYMER USING RECOMBINANT MICROORGANISM | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2011-05-05 | — | — | US | disclosed |
| EP-2284261-A1 | METHOD FOR PRODUCTION OF POLYESTER COPOLYMER USING GENETICALLY MODIFIED MICROORGANISM | National University Corporation Hokkaido University (JP) | 2011-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263526-A1 | Nitric Oxide Releasing Prodrugs of Therapeutic Agents | NOS2, NOS1, NOS3 | GABBR2 1862/4885GABBR1 1932/4885CAMK2A 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.