Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174224 | 0.84 | S1PR1 (0.35) | S1PR5S1PR1PRKXACVR1NPC1 | |
| SCHEMBL5507807 | 0.80 | HRH3 (0.39) | S1PR5S1PR1PRKXACVR1NPC1 | |
| SCHEMBL1092839 | 0.74 | NPC1 (0.49) | S1PR5S1PR1PRKXACVR1NPC1 | |
| SCHEMBL1092836 | 0.74 | NPC1 (0.49) | S1PR5S1PR1PRKXACVR1NPC1 | |
| SCHEMBL4187799 | 0.73 | PRKDC (0.38) | S1PR5S1PR1PRKXACVR1NPC1 | |
| SCHEMBL4067724 | 0.72 | HRH3 (0.39) | S1PR5S1PR1PRKXACVR1GRIN1 | |
| SCHEMBL4196923 | 0.71 | HPGD (0.42) | HRH3 | |
| SCHEMBL5502793 | 0.71 | GRM2 (0.39) | — | |
| SCHEMBL4190944 | 0.70 | MAPK14 (0.33) | — | |
| SCHEMBL1093210 | 0.69 | PRKDC (0.42) | S1PR5S1PR1PRKXACVR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |