Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180585 | 0.84 | S1PR5 (0.40) | S1PR1PRKXACVR1S1PR5HRH3 | |
| SCHEMBL4186193 | 0.79 | PDE4B (0.34) | — | |
| SCHEMBL1092695 | 0.77 | FDFT1 (0.37) | S1PR1PRKXACVR1S1PR5FDFT1 | |
| SCHEMBL1092697 | 0.77 | FDFT1 (0.37) | S1PR1PRKXACVR1S1PR5FDFT1 | |
| SCHEMBL4192647 | 0.75 | HRH3 (0.39) | ACVR1HRH3L3MBTL1 | |
| SCHEMBL4191491 | 0.75 | MAPK14 (0.32) | — | |
| SCHEMBL4179199 | 0.74 | PDE5A (0.34) | HRH3 | |
| SCHEMBL207726 | 0.73 | CREBBP (0.34) | S1PR1PRKXACVR1S1PR5FDFT1 | |
| SCHEMBL210843 | 0.71 | HSD11B1 (0.43) | S1PR1PRKXACVR1S1PR5FDFT1 | |
| SCHEMBL210841 | 0.71 | HSD11B1 (0.43) | S1PR1PRKXACVR1S1PR5FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |