Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA4 | P22748 | 3/20 | 0.40 |
| ▸ | CA5A | P35218 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036800 | 0.88 | GAA (0.47) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL12527462 | 0.79 | CYP1A2 (0.47) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL12493846 | 0.79 | CYP1A2 (0.47) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL1715829 | 0.76 | CYP1A2 (0.53) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL12525349 | 0.75 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1715165 | 0.74 | CYP1A2 (0.57) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL547427 | 0.74 | CYP1A2 (0.50) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL548039 | 0.74 | CYP1A2 (0.50) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL5089500 | 0.73 | CYP1A2 (0.55) | GAACYP1A2CA12CA1CA2 | |
| SCHEMBL14930772 | 0.73 | CYP1A2 (0.55) | GAACYP1A2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9896437-B2 | Diarylhydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-20 | — | — | US | disclosed |
| US-9896437-B2 | Diarylhydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-20 | — | — | US | disclosed |
| EP-2683694-B1 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF | SUZHOU KINTOR PHARMACEUTICALS INC (CN) | 2016-04-27 | — | — | EP | disclosed |
| US-9216957-B2 | Androgen receptor antagonists and uses thereof | SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) | 2015-12-22 | — | — | US | disclosed |
| US-9216957-B2 | Androgen receptor antagonists and uses thereof | SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) | 2015-12-22 | — | — | US | disclosed |
| US-20150065546-A1 | DIARYLHYDANTOIN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-05 | — | — | US | disclosed |
| US-20150065546-A1 | DIARYLHYDANTOIN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-05 | — | — | US | disclosed |
| US-8680291-B2 | Diarylhydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-03-25 | — | — | US | disclosed |
| US-8680291-B2 | Diarylhydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-03-25 | — | — | US | disclosed |
| US-20140066425-A1 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF | SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) | 2014-03-06 | — | — | US | disclosed |
| US-20140066425-A1 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF | SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) | 2014-03-06 | — | — | US | disclosed |
| EP-2620432-A2 | Diarylhydantoin compounds | The Regents Of the University of California (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012119559-A1 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF | SUZHOU KINTOR PHARMACEUTICALS,INC. (CN) | 2012-09-13 | — | — | WO | disclosed |
| EP-2397469-A1 | Diarylhydantoin compounds | The Regents Of the University of California (US) | 2011-12-21 | — | — | EP | disclosed |
| US-20090111864-A1 | DIARYLHYDANTOIN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-30 | — | — | US | disclosed |
| US-20090111864-A1 | DIARYLHYDANTOIN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-30 | — | — | US | disclosed |
| WO-2009055053-A2 | DIARYLHYDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065546-A1 | DIARYLHYDANTOIN COMPOUNDS | BPHL, ACP3, AR | GAA 4715/4885CYP1A2 1363/4885CA12 237/4885 |
| US-20140066425-A1 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF | AR, SHBG, NR5A1 | GAA 3773/4885CYP1A2 911/4885CA12 4443/4885 |
| US-20090111864-A1 | DIARYLHYDANTOIN COMPOUNDS | BPHL, ACP3, AR | GAA 4715/4885CYP1A2 1363/4885CA12 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.