SCHEMBL4181653

SCHEMBL4181653

CCCCOC(=O)[N]c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.54
TDP1 Q9NUW8 4/20 0.54
L3MBTL1 Q9Y468 3/20 0.54
ALDH1A1 P00352 5/20 0.49
MAPK1 P28482 3/20 0.49
CYP3A4 P08684 3/20 0.49
TP53 P04637 1/20 0.49
HSD17B10 Q99714 2/20 0.47
LMNA P02545 4/20 0.47
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP1A2 P05177 3/20 0.44
CYP2C19 P33261 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
ESR1 P03372 1/20 0.44
CYP2D6 P10635 1/20 0.44
NR1H2 P55055 1/20 0.44
RNASEL Q05823 1/20 0.44
BCHE P06276 1/20 0.43
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9847717 0.93 TSHR (0.57) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL8076539 0.93 TSHR (0.57) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL5690919 0.89 LMNA (0.55) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL283224 0.82 ALDH1A1 (0.51) TSHRTDP1ALDH1A1HSD17B10MEN1
SCHEMBL15843546 0.76 TSHR (0.50) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL15843752 0.76 ALDH1A1 (0.64) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL3868730 0.76 TDP1 (0.58) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL15843547 0.76 TSHR (0.50) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL27884133 0.76 TDP1 (0.51) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL15843751 0.76 ALDH1A1 (0.64) TSHRTDP1L3MBTL1ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009093013-A1 FUSED THIOPHENE DERIVATIVES AS MEK INHIBITORS UCB PHARMA S.A. (BE) 2009-07-30 WO disclosed
EP-1146037-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AMINO ALCOHOLS NIPPON SODA CO (JP) 2006-06-21 EP disclosed
US-6410749-B1 REACTING A CARBONYL COMPOUND WITH ORGANOMETALLIC COMPOUND NIPPON SODA CO., LTD. (JP) 2002-06-25 US disclosed
EP-1146037-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AMINO ALCOHOLS NIPPON SODA CO., LTD. (JP) 2001-10-17 EP disclosed
US-4889869-A ANTIALDOSTERONISM AGENTS CIBA-GEIGY CORPORATION (US) 1989-12-26 US disclosed