Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195314 | 0.91 | MAPT (0.42) | LMNAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4193470 | 0.91 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL13653188 | 0.89 | HDAC1 (0.43) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4190646 | 0.87 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4189862 | 0.86 | HDAC1 (0.46) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL13653112 | 0.86 | GCGR (0.40) | HDAC1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4186733 | 0.86 | HDAC3 (0.45) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL13653189 | 0.85 | HDAC1 (0.45) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4192728 | 0.85 | HDAC1 (0.45) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL27688294 | 0.84 | MEN1 (0.39) | LMNAMAPTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247590-A1 | Indane amides | BAYER PHARMACEUTICLAS CORPORATION (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247590-A1 | Indane amides | BAYER PHARMACEUTICLAS CORPORATION (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247590-A1 | Indane amides | BAYER PHARMACEUTICLAS CORPORATION (US) | 2009-10-01 | — | — | US | disclosed |
| EP-1802577-A1 | INDANE AMIDES WITH ANTIPROLIFERATIVE ACTIVITY | Bayer Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006062580-A1 | INDANE AMIDES WITH ANTIPROLIFERATIVE ACTIVITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247590-A1 | Indane amides | MKI67, PPIP5K2, CCNA1 | HDAC1 579/4885HDAC3 1045/4885HDAC2 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.