Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | NCOR1 | O75376 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13653189 | 0.92 | HDAC1 (0.45) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4192728 | 0.92 | HDAC1 (0.45) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4190646 | 0.91 | HDAC1 (0.48) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4186733 | 0.90 | HDAC3 (0.45) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4190641 | 0.89 | HDAC1 (0.43) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL13653188 | 0.89 | HDAC1 (0.43) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4193470 | 0.88 | HDAC1 (0.48) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4184358 | 0.87 | HDAC1 (0.48) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4183198 | 0.86 | HDAC1 (0.43) | HDAC1HDAC2HDAC3NCOR2HDAC8 | |
| SCHEMBL4189915 | 0.86 | HDAC1 (0.53) | HDAC1HDAC2HDAC3NCOR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247590-A1 | Indane amides | BAYER PHARMACEUTICLAS CORPORATION (US) | 2009-10-01 | — | — | US | disclosed |
| EP-1802577-A1 | INDANE AMIDES WITH ANTIPROLIFERATIVE ACTIVITY | Bayer Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006062580-A1 | INDANE AMIDES WITH ANTIPROLIFERATIVE ACTIVITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247590-A1 | Indane amides | MKI67, PPIP5K2, CCNA1 | HDAC1 579/4885HDAC2 641/4885HDAC3 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.