Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350856 | 0.91 | EGFR (0.75) | EGFRERBB2ERBB4 | |
| SCHEMBL4199597 | 0.85 | EGFR (0.83) | EGFRERBB2ERBB4 | |
| SCHEMBL4201064 | 0.83 | EGFR (0.72) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL7219786 | 0.82 | EGFR (0.71) | EGFRERBB2ERBB4 | |
| SCHEMBL4191508 | 0.78 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL4190264 | 0.77 | EGFR (0.72) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL8580434 | 0.77 | EGFR (0.72) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL2251606 | 0.77 | EGFR (0.75) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL4194453 | 0.76 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL2994028 | 0.76 | EGFR (1.00) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |