Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 12/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183199 | 0.91 | EGFR (0.62) | EGFRERBB2ERBB4 | |
| SCHEMBL4194453 | 0.86 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL2994881 | 0.84 | EGFR (0.62) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL2994887 | 0.84 | EGFR (0.62) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4187462 | 0.84 | EGFR (0.75) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7220678 | 0.82 | EGFR (0.75) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7220061 | 0.80 | EGFR (0.79) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4184905 | 0.79 | EGFR (0.65) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL4184896 | 0.77 | EGFR (0.78) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4187517 | 0.77 | EGFR (0.85) | EGFRERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |