Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.47 |
| ▸ | RPA1 | P27694 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922038 | 0.75 | RPA1 (0.63) | RPA1ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL4174561 | 0.73 | JAK2 (0.55) | GAAS1PR4ALDH1A1KMT2A | |
| SCHEMBL4182153 | 0.71 | NPC1 (0.63) | GAAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL1180133 | 0.68 | RPA1 (0.42) | RPA1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1180189 | 0.68 | RPA1 (0.42) | RPA1ALDH1A1KDM4ESCN10A | |
| SCHEMBL4631024 | 0.65 | CNR2 (0.43) | RPA1 | |
| SCHEMBL4896592 | 0.64 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL110247 | 0.63 | AHR (0.52) | S1PR4ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL3055514 | 0.63 | RPA1 (0.78) | GAARPA1ALDH1A1NPC1RAB9A | |
| SCHEMBL19556314 | 0.63 | RPA1 (0.78) | RPA1ALDH1A1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| WO-2007090494-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | CHEK1, CHEK2, SGK3 | GAA 3878/4885RPA1 430/4885S1PR4 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.