Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20984437 | 0.73 | GAA (0.58) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL15135520 | 0.72 | GAA (0.57) | GAAALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL4184540 | 0.71 | GAA (0.47) | NPC1RAB9AGAAALDH1A1HPGD | |
| SCHEMBL18150249 | 0.70 | GAA (0.53) | RAB9AGAAALDH1A1MAPTTDP1 | |
| SCHEMBL20011707 | 0.70 | GAA (0.54) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL4020988 | 0.70 | RAB9A (0.70) | NPC1RAB9AALDH1A1GRM4MAPT | |
| SCHEMBL4174561 | 0.69 | JAK2 (0.55) | GAAALDH1A1MAPTKMT2A | |
| SCHEMBL7159563 | 0.69 | ALDH1A1 (1.00) | RAB9AGAAALDH1A1MAPTTHRB | |
| SCHEMBL31337431 | 0.69 | MAPT (0.70) | NPC1RAB9AGAAALDH1A1GRM4 | |
| SCHEMBL28844978 | 0.68 | GAA (0.60) | NPC1RAB9AGAAALDH1A1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| WO-2007090494-A1 | AMINO INDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036508-A1 | AMINO INDAZOLE DERIVATIVES | CHEK1, CHEK2, SGK3 | NPC1 3540/4885RAB9A 3269/4885GAA 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.