Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860036 | 0.81 | CSF1R (0.52) | CSF1RHDAC2HDAC1HDAC3 | |
| SCHEMBL4187757 | 0.73 | CA12 (0.34) | — | |
| SCHEMBL10583976 | 0.72 | CYP3A4 (0.40) | HDAC2HDAC1HDAC3GRM2PSMB5 | |
| SCHEMBL3082188 | 0.71 | CSF1R (0.45) | CSF1RHDAC2HDAC1HDAC3GRM2 | |
| SCHEMBL3082208 | 0.70 | PSMB5 (0.36) | CSF1RHDAC2HDAC1HDAC3PSMB5 | |
| SCHEMBL4179494 | 0.69 | CSF1R (0.52) | CSF1RHDAC2HDAC1HDAC3GRM2 | |
| SCHEMBL1860797 | 0.69 | CSF1R (0.51) | CSF1RHDAC2HDAC1HDAC3CCNE1 | |
| SCHEMBL4183536 | 0.69 | MAPT (0.47) | — | |
| SCHEMBL4333962 | 0.69 | CSF1R (0.56) | CSF1RHDAC2HDAC1HDAC3FFAR2 | |
| SCHEMBL14405148 | 0.69 | CSF1R (0.56) | CSF1RHDAC2HDAC1HDAC3FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124316-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |