Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138166 | 0.81 | GAA (0.41) | MAPTGSK3BALDH1A1CYP3A4 | |
| SCHEMBL11359163 | 0.81 | HDAC8 (0.50) | CYP19A1MEN1KMT2ACRBNDDB1 | |
| SCHEMBL31139945 | 0.79 | GLA (0.60) | MAPTCYP19A1GSK3BKMT2AGLA | |
| SCHEMBL4187757 | 0.77 | CA12 (0.34) | CYP19A1GSK3BGLA | |
| SCHEMBL7446113 | 0.73 | MEN1 (0.49) | MEN1KMT2AGFERALDH1A1CYP3A4 | |
| SCHEMBL1859440 | 0.71 | CYP19A1 (0.61) | MAPTCYP19A1GSK3BCRBNDDB1 | |
| SCHEMBL7438487 | 0.70 | NFE2L2 (0.47) | MEN1KMT2AGFERALDH1A1CYP3A4 | |
| SCHEMBL1264017 | 0.69 | GBA1 (0.66) | MEN1KMT2AGFERALDH1A1CYP3A4 | |
| SCHEMBL11926046 | 0.68 | MAPT (0.53) | MAPTCYP19A1GSK3BGFERALDH1A1 | |
| SCHEMBL3155441 | 0.68 | NFE2L2 (0.50) | MEN1KMT2AGFERALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124316-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |