Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439150 | 0.79 | SLC6A4 (0.39) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4183536 | 0.77 | MAPT (0.47) | CYP19A1GLAGSK3B | |
| SCHEMBL7437741 | 0.76 | SLC6A4 (0.38) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4184781 | 0.73 | CSF1R (0.37) | — | |
| SCHEMBL1859696 | 0.73 | CYP19A1 (0.40) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4138166 | 0.70 | GAA (0.41) | BACE1GSK3B | |
| SCHEMBL11359163 | 0.70 | HDAC8 (0.50) | CA2CYP19A1 | |
| SCHEMBL1300912 | 0.66 | GAA (0.54) | CA12CA1CA2CA4CA6 | |
| SCHEMBL7450435 | 0.65 | CA2 (0.50) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11441801 | 0.65 | LOXL2 (0.44) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124316-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |