Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483730 | 0.85 | KDM4E (0.48) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4486505 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4196150 | 0.78 | KDM4E (0.46) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4195268 | 0.75 | KDM4E (0.43) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4193683 | 0.75 | KDM4E (0.46) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4181685 | 0.74 | KDM4E (0.50) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4187070 | 0.74 | KDM4E (0.52) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL4191386 | 0.74 | LMNA (0.44) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4193769 | 0.74 | MEN1 (0.42) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4191934 | 0.74 | KDM4E (0.43) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |