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SCHEMBL4187218

SCHEMBL4187218

CC(C)(C)[Si](OC1CCC(C(c2c(Cl)cc(-c3ccc(C(=O)N4CCC(C(F)(F)F)CC4)cc3)cc2Cl)C2CCNC2=O)CC1)(c1ccccc1)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ HTR2B P41595 5/20 0.34
▸ ALK Q9UM73 1/20 0.34
▸ MGLL Q99685 4/20 0.34
▸ NAMPT P43490 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ SPR P35270 4/20 0.33
▸ HPGD P15428 1/20 0.33
▸ FASN P49327 1/20 0.33
▸ CCNC P24863 1/20 0.32
▸ CDK8 P49336 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4181006 0.89 HTR2B (0.34) HTR2BALKMGLLNAMPTLMNA
SCHEMBL4194240 0.82 SPR (0.38) HTR2BNAMPTLMNASPRHPGD
SCHEMBL209201 0.78 HDAC4 (0.41) —
SCHEMBL208778 0.77 MEN1 (0.32) —
SCHEMBL209158 0.77 MEN1 (0.32) —
SCHEMBL2299336 0.77 NAMPT (0.33) HTR2BALKMGLLNAMPTLMNA
SCHEMBL1751913 0.76 RIPK1 (0.39) HTR2BALKMGLLNAMPTLMNA
SCHEMBL2299402 0.75 NAMPT (0.36) HTR2BALKMGLLNAMPTLMNA
SCHEMBL208541 0.75 SRD5A2 (0.32) —
SCHEMBL4060990 0.75 SRD5A2 (0.32) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2021337-A2 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2009-02-11 — — EP disclosed
WO-2007127726-A2 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-11-08 — — WO disclosed