Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 4/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191546 | 1.00 | SUCNR1 (0.42) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL4192558 | 1.00 | SUCNR1 (0.42) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL13625412 | 0.90 | MEN1 (0.41) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL4178661 | 0.88 | CETP (0.45) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL4181225 | 0.88 | CETP (0.45) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL4185837 | 0.88 | CETP (0.45) | SUCNR1ADORA2BSORT1CETPMTOR | |
| SCHEMBL4455320 | 0.85 | CETP (0.48) | SUCNR1ADORA2BSORT1CETPMEN1 | |
| SCHEMBL4193109 | 0.85 | CETP (0.48) | SUCNR1ADORA2BSORT1CETPMEN1 | |
| SCHEMBL4464924 | 0.85 | CETP (0.48) | SUCNR1ADORA2BSORT1CETPMEN1 | |
| SCHEMBL4190731 | 0.84 | SUCNR1 (0.38) | SUCNR1KDM1AHDAC1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275515-A1 | 2-HYDROXY-2-PHENYLTHIOPHENYLPROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2009-11-05 | — | — | US | disclosed |
| EP-2083624-A2 | 2-HYDROXY-2-PHENYL/THIOPHENYL PROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008048540-A2 | 2-HYDROXY-2-PHENYL/THIOPHENYL PROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275515-A1 | 2-HYDROXY-2-PHENYLTHIOPHENYLPROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS | SHBG, AR, FSHR | SUCNR1 2093/4885ADORA2B 1725/4885SORT1 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.