SCHEMBL4187726

SCHEMBL4187726

O=C(Nc1c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1SC(F)(F)F)c1cccc(NC(=O)c2cccnc2Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 2/20 0.42
PTGES O14684 1/20 0.41
MAPT P10636 3/20 0.41
CSF1R P07333 2/20 0.40
MAPK1 P28482 1/20 0.39
RXFP1 Q9HBX9 4/20 0.39
RHOC P08134 1/20 0.38
RHOA P61586 1/20 0.38
KDM4E B2RXH2 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CES1 P23141 1/20 0.37
EPHX2 P34913 1/20 0.37
KCNK3 O14649 1/20 0.37
KCNK9 Q9NPC2 1/20 0.37
GFER P55789 1/20 0.37
NR2E3 Q9Y5X4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13875604 0.88 KMT2A (0.50) MEN1KMT2AALDH1A1MAPTCSF1R
SCHEMBL1766654 0.87 MEN1 (0.51) MEN1KMT2AALDH1A1PTGESMAPT
SCHEMBL1767081 0.87 MEN1 (0.53) MEN1KMT2AALDH1A1PTGESMAPT
SCHEMBL4192114 0.85 MEN1 (0.50) MEN1KMT2APTGESMAPTRXFP1
SCHEMBL4187134 0.85 KCNK3 (0.49) MEN1KMT2APTGESMAPTRXFP1
SCHEMBL1829876 0.83 MEN1 (0.54) MEN1KMT2AALDH1A1PTGESMAPT
SCHEMBL1767273 0.83 MEN1 (0.48) MEN1KMT2AALDH1A1PTGESMAPT
SCHEMBL1767168 0.82 MEN1 (0.55) MEN1KMT2AALDH1A1PTGESMAPT
SCHEMBL4175359 0.81 MAPT (0.39) MEN1KMT2AMAPTRXFP1RHOC
SCHEMBL1766529 0.81 MEN1 (0.53) MEN1KMT2AALDH1A1PTGESMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2009-04-16 US disclosed
EP-1916236-A1 AMIDE DERIVATIVE, PESTICIDE CONTAINING SUCH COMPOUND AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2008-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide CYP2E1, GSTA1, CYP2S1 MEN1 4524/4885KMT2A 499/4885ALDH1A1 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.