SCHEMBL13875604

SCHEMBL13875604

Cc1cc(Br)c(NC(=O)c2cccc(NC(=O)c3cccnc3Cl)c2)c(SC(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.50
MEN1 O00255 2/20 0.50
KCNK3 O14649 4/20 0.44
KCNK9 Q9NPC2 4/20 0.44
ALDH1A1 P00352 2/20 0.43
MAPT P10636 2/20 0.42
CSF1R P07333 4/20 0.41
MAPK1 P28482 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
BRAF P15056 2/20 0.40
POLB P06746 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4187726 0.88 MEN1 (0.48) KMT2AMEN1KCNK3KCNK9ALDH1A1
SCHEMBL13875614 0.84 KMT2A (0.51) KMT2AMEN1KCNK3KCNK9MAPT
SCHEMBL13875603 0.81 MEN1 (0.42) KMT2AMEN1KCNK3KCNK9MAPT
SCHEMBL2102844 0.80 MEN1 (0.51) KMT2AMEN1KCNK3KCNK9ALDH1A1
SCHEMBL1829876 0.79 MEN1 (0.54) KMT2AMEN1ALDH1A1MAPTCSF1R
SCHEMBL1361068 0.78 MEN1 (0.48) KMT2AMEN1KCNK3KCNK9ALDH1A1
SCHEMBL1767081 0.78 MEN1 (0.53) KMT2AMEN1ALDH1A1MAPTCSF1R
SCHEMBL1766654 0.77 MEN1 (0.51) KMT2AMEN1KCNK3KCNK9ALDH1A1
SCHEMBL18023941 0.77 MEN1 (0.53) KMT2AMEN1ALDH1A1MAPTCSF1R
SCHEMBL18023939 0.77 MEN1 (0.53) KMT2AMEN1ALDH1A1MAPTCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2009-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide CYP2E1, GSTA1, CYP2S1 KMT2A 499/4885MEN1 4524/4885KCNK3 504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.