Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 19/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13747310 | 0.72 | PGR (0.47) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL4193038 | 0.71 | CES1 (0.46) | PGRARNR3C1ESR1NR3C2 | |
| SCHEMBL5498846 | 0.68 | PGR (0.43) | PGRARNR3C1ESR1NR3C2 | |
| SCHEMBL5506049 | 0.67 | PGR (0.44) | PGRARNR3C1ESR1NR3C2 | |
| SCHEMBL5508770 | 0.65 | ALDH1A1 (0.38) | PGRARNR3C1KDM4EALDH1A1 | |
| SCHEMBL5504578 | 0.65 | CES1 (0.46) | PGRARKDM4EALDH1A1LMNA | |
| SCHEMBL4207661 | 0.65 | PGR (0.53) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL5495793 | 0.62 | ALDH1A1 (0.41) | PGRKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL10840500 | 0.61 | ALDH1A1 (0.53) | PGRKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL18885784 | 0.59 | HDAC1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103007-A2 | STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-08-20 | — | — | WO | disclosed |