Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011154 | 0.90 | KDM4E (0.48) | YAP1KDM4EALDH1A1PKMMMP13 | |
| Trifluoroacetic Acid SCHEMBL1011579 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1PKMMMP13ADAMTS5 | |
| SCHEMBL13280881 | 0.86 | PRMT5 (0.49) | YAP1PRMT5MAOAMAOBPPARG | |
| Trifluoroacetic Acid SCHEMBL1010326 | 0.81 | FAAH (0.49) | — | |
| SCHEMBL15441571 | 0.80 | YAP1 (0.52) | YAP1PRMT5MAOAMAOBPPARG | |
| Tert-Butyl Formate SCHEMBL27785453 | 0.79 | MAOB (0.52) | KDM4EALDH1A1PKMMMP13ADAMTS5 | |
| Hydrochloric Acid SCHEMBL4184397 | 0.79 | FAAH (0.47) | ADAMTS5GHSR | |
| SCHEMBL1011580 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1PKMMMP13ADAMTS5 | |
| SCHEMBL1011417 | 0.77 | ABCB1 (0.44) | KDM4EALDH1A1ADAMTS5GHSRMEN1 | |
| SCHEMBL6396022 | 0.76 | ABCB1 (0.48) | KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |