SCHEMBL4188926

SCHEMBL4188926

CN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2OCC(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UGCG Q16739 2/20 0.42
NR1H3 Q13133 2/20 0.38
NR1H2 P55055 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
MAPT P10636 6/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
HTT P42858 3/20 0.36
MRGPRX4 Q96LA9 3/20 0.36
MAPK14 Q16539 1/20 0.36
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MDM2 Q00987 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13875630 0.86 UGCG (0.40) UGCGNR1H3NR1H2RXFP1MAPT
SCHEMBL1766724 0.86 MAPT (0.43) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL13890496 0.85 UGCG (0.41) UGCGRXFP1MAPTMEN1KMT2A
SCHEMBL1766807 0.84 NR1H3 (0.43) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL1766921 0.81 MAPT (0.41) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL4183073 0.81 NR1H3 (0.40) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL4185079 0.81 NR1H3 (0.39) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL1766411 0.80 NR1H3 (0.46) NR1H3NR1H2RXFP1MAPTMEN1
SCHEMBL12356427 0.80 RXFP1 (0.45) NR1H3NR1H2RXFP1MAPTMAPK14
SCHEMBL22402096 0.80 ITK (0.41) NR1H3MAPK14SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2009-04-16 US disclosed
EP-1916236-A1 AMIDE DERIVATIVE, PESTICIDE CONTAINING SUCH COMPOUND AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2008-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide CYP2E1, GSTA1, CYP2S1 UGCG 2020/4885NR1H3 362/4885NR1H2 384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.