Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2958352 | 0.98 | ALDH1A1 (0.40) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL8386845 | 0.98 | ALDH1A1 (0.40) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL8386840 | 0.97 | ALDH1A1 (0.39) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL2952880 | 0.76 | KDM4E (0.34) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL3968660 | 0.71 | KMT2A (0.51) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL2953593 | 0.70 | KMT2A (0.54) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL2956995 | 0.68 | KMT2A (0.62) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL6937968 | 0.67 | ALDH1A1 (0.54) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL30663865 | 0.67 | KMT2A (0.60) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 | |
| Bromide SCHEMBL8652311 | 0.67 | KMT2A (0.60) | ALDH1A1KMT2AAPOBEC3GKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808163-B1 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON INC (US) | 2003-07-23 | — | — | EP | claimed |
| US-6440749-B1 | ADMINISTERING A THIAZOLE COMPOUND | ALTEON. INC. | 2002-08-27 | — | — | US | claimed |
| EP-3020711-B1 | THIAZOLE INNER SALT COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-05-22 | — | — | EP | disclosed |
| US-8338616-B2 | Thiazoliums and their use for treating protein aging associated diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2012-12-25 | — | — | US | disclosed |
| US-20110178141-A1 | Thiazoliums and Their Use for Treating Protein Aging Associated Diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2011-07-21 | — | — | US | disclosed |
| WO-2009023207-A1 | THIAZOLIUM COMPOUNDS FOR TREATING GASTROINTESTINAL COMPLICATIONS | SYNVISTA THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
| US-RE38330-E1 | Preventing and reversing advanced glycosylation endproducts | ALTEON INC. | 2003-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178141-A1 | Thiazoliums and Their Use for Treating Protein Aging Associated Diseases | TTR, MTPN, TFEB | ALDH1A1 2281/4885KMT2A 3940/4885APOBEC3G 4497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.